Estramustine
Estramustine(NSC-89201, LEO275) is used to treat hormone-resistant prostate cancer and stabilize microtubule dynamics. It acts as an anti-mitotic and anti-microtubule agent and disrupts microtubule disassembly. It inhibits the binding of MAPs 1 and 2 to taxol-stabilized microtubules, hinders microtubule assembly, and promotes the disassembly of MAP-2-associated microtubules.
| Trivial name | NSC-89201, LEO275 |
| Catalog Number | E4897 |
| Molecular Formula | C17H14ClF2N3O3S |
| CAS# | 2998-57-4 |
| Inchi | InChI=1S/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22) |
| Inchi Key | YZDJQTHVDDOVHR-UHFFFAOYSA-N |
| SMILES | CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)Cl)F |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/estramustine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4897-Estramustine-chemical-structure.png |