TRK-IN-28 | MedChemExpress (MCE)

TRK-IN-28 (compound 30f) is a TRK inhibitor with the IC50 values of 0.55 nM, 25.1 nM and 5.4 nM against TRKWT, TRKG595R and TRKG667C, respectively. TRK-IN-2 shows antiproliferative activity with IC50 values of 9.5, 3.7, 205.0 and 48.3 nM against Ba/F3-ETV6-TRKAWT, Ba/F3-ETV6-TRKBWT, Ba/F3-LMNA-TRKG595R and Ba/F3-LMNA-TRKAG667C, respectively[1].

Trivial name TRK-IN-28
Catalog Number HY-163366
Research Area Cancer
CAS# 2991504-43-7
Purity ≥98.0%
SMILES FC1=CC(CC2=CC3=C(NN=C3NC4=C5C=CC(N6CCN(CC6)C)=CC5=NC=N4)C=C2)=CC(F)=C1
Size 1 mg
Supplier Page https://www.medchemexpress.com/trk-in-28.html