ATX968
ATX968 (DHX9-IN-2) is a potent, selective, and orally bioavailable inhibitor of DHX9 helicase with an IC50 of 8 nM. It induces strong and sustained tumor growth inhibition or regression in MSI-H/dMMR colorectal cancer (CRC) xenograft models.
| Trivial name | DHX9-IN-2 |
| Catalog Number | E5836 |
| Molecular Formula | C17H21NO3 |
| CAS# | 2973395-71-8 |
| Inchi | InChI=1S/C17H21NO3/c1-3-11-6-5-7-12-13-8-9-21-17(4-2,10-14(19)20)16(13)18-15(11)12/h5-7,18H,3-4,8-10H2,1-2H3,(H,19,20)/t17-/m1/s1 |
| Inchi Key | NNYBQONXHNTVIJ-QGZVFWFLSA-N |
| SMILES | CCC1=C2C(=CC=C1)C3=C(N2)C(OCC3)(CC)CC(=O)O |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/atx968.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5836-ATX968-chemical-structure.png |