WH244
WH244 is a second-generation PROTAC that selectively degrades the anti-apoptotic proteins BCL-xL and BCL-2 with a DC50 of 0.6 nM for BCL-xL and 7.4 nM for BCL-2.
| Catalog Number | E8278 |
| Molecular Formula | C27H44O7 |
| CAS# | 2941088-96-4 |
| Inchi | InChI=1S/C27H44O7/c1-23(2,32)9-8-22(31)26(5,33)21-7-11-27(34)16-12-18(28)17-13-19(29)20(30)14-24(17,3)15(16)6-10-25(21,27)4/h12,15,17,19-22,29-34H,6-11,13-14H2,1-5H3/t15-,17-,19+,20-,21-,22+,24+,25+,2 6+,27+/m0/s1 |
| Inchi Key | NKDFYOWSKOHCCO-YPVLXUMRSA-N |
| SMILES | CC12CCC3C(=CC(=O)C4C3(CC(C(C4)O)O)C)C1(CCC2C(C)(C(CCC(C)(C)O)O)O)O |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/wh244.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E8278-WH244-chemical-structure.png |