YB-3-17
YB-3−17 is a dual-target compound that effectively and selectively inhibits mTOR with an IC50 of 0.22 nM, while promoting GSPT1 degradation with an IC50 of 5 nM, leading to substantial tumor growth inhibition both in vitro and in vivo. It also exhibits significant antiproliferative activity in glioblastoma models.
| Catalog Number | E5815 |
| Molecular Formula | C21H18NO4.HCl |
| CAS# | 2940242-88-4 |
| Inchi | InChI=1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H/q+1; |
| Inchi Key | WEEFNMFMNMASJY-UHFFFAOYSA-N |
| SMILES | C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5.[Cl-] |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/yb-3-17.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5815-YB-3-17-chemical-structure.png |