BI-2865

BI-2865 is a non-covalent pan-KRAS inhibitor.BI-2865 binds to KRAS WT, G12C, G12D, G12V, and G13D mutants with KD values of 6.9, 4.5, 32, 26, and 4.3 nM, respectively.BI-2865 showed antiproliferative activity in BaF3 cells expressing KRAS G12C, G12D, or G12V mutants. BI-2865 showed antiproliferative activity on BaF3 cells expressing KRAS G12C, G12D or G12V mutants with an average IC50 value of approximately 140 nM.

Price Not Available 1 mg BI-2865 Supplier Page

Catalog Number	T72062
Research Area	MAPK\|\|\|GPCR/G Protein
Molecular Formula	C23H27N7O2S
CAS#	2937327-93-8
SMILES	C[C@]1(C2=C(SC(N)=C2C#N)CCC1)C3=NC(=NO3)C=4N=C(O[C@@H](C)[C@@]5(CCCN5C)[H])C=CN4
Size	1 mg
Supplier Page	https://www.targetmol.com/compound/bi-2865
Additional Information	https://www.targetmol.com/datasheet/T72062