ATC-324
ATC-324 is a potent AUTOphagy-TArgeting Chimera (AUTOTAC) degrader of androgen receptor (AR) with a DC50 of 2.05 µM. It induces autophagy–lysosomal degradation of AR, reduces nuclear AR and AR-V7 activity, and causes cytotoxicity in AR-positive prostate cancer cells, making it useful for prostate cancer research.
| Catalog Number | E8305 |
| Molecular Formula | C21H25NO4 |
| CAS# | 2925060-81-5 |
| Inchi | InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1 |
| Inchi Key | AEQDJSLRWYMAQI-KRWDZBQOSA-N |
| SMILES | COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/atc-324.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e8305-atc-324-chemical-structure-tube.png |