ATUX-1215
ATUX-1215 is an orally bioavailable diarylmethyl-4-aminopyran sulfonamide that activates protein phosphatase 2A (PP2A) by stabilizing AC heterodimers and promoting heterotrimer formation with B subunits. It restores suppressed PP2A activity in IPF models, improving lung function, reducing collagen deposition, and downregulating fibrotic cytokines. ATUX-1215 also exhibits potent antifibrotic effects.
| Catalog Number | E8281 |
| Molecular Formula | C15H13N3O2S |
| CAS# | 2910929-53-0 |
| Inchi | InChI=1S/C15H13N3O2S/c1-20-11-7-8-12-13(9-11)21-15(17-12)18-14(19)16-10-5-3-2-4-6-10/h2-9H,1H3,(H2,16,17,18,19) |
| Inchi Key | JHBWYQRKOUBPCA-UHFFFAOYSA-N |
| SMILES | COC1=CC2=C(C=C1)N=C(S2)NC(=O)NC3=CC=CC=C3 |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/atux-1215.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E8281-ATUX-1215-chemical-structure.png |