BBO-8520 | MedChemExpress (MCE)
BBO-8520 is a direct small molecule covalent inhibitor targeting KRAS G12C with high oral availability. BBO-8520 has the characteristics of KRAS G12C (OFF) inhibitor and the function of blocking KRAS G12C (ON) signal. BBO-8520 inhibits cell proliferation by inhibiting KRAS G12C (ON) by binding GTP protein. BBO-8520 can block RAS-RAF1 interaction and return KRAS G12C to the inactive (OFF) state [1].
| Trivial name | BBO-8520 |
| Catalog Number | HY-158107 |
| Research Area | Cancer |
| CAS# | 2893809-51-1 |
| Purity | ≥98.0% |
| SMILES | FC1=[C@](C(C(F)(F)F)=CC2=C(N=C(N=C21)OC[C@@]34CCCN3C[C@@H](C4)F)N5[C@H](CN([C@@H](C5)C)C(C=C)=O)C)[C@]6=CC=C(F)C7=C6C(C#N)=C(N)S7 |
| Size | 10 mg |
| Supplier Page | https://www.medchemexpress.com/bbo-8520.html |