Cediranib (AZD2171)
Cediranib (AZD2171, NSC-732208) is a highly potent VEGFR(KDR) inhibitor with IC50 of <1 nM, also inhibits Flt1/4 with IC50 of 5 nM/≤3 nM, similar activity against c-Kit and PDGFRβ, 36-, 110-fold and >1000-fold selective more for VEGFR than PDGFR-α, CSF-1R and Flt3 in HUVEC cells. Cediranib (AZD2171) induces autophagic vacuole accumulation. Phase 3.
| Trivial name | NSC-732208 |
| Catalog Number | S1017 |
| Molecular Formula | C7H4NNaO3S.xH2O |
| CAS# | 288383-20-0 |
| SMILES | C1=CC=C2C(=C1)C(=O)[N-]S2(=O)=O.O.[Na+] |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/Cediranib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Cediranib-AZD2171-chemical-structure-S1017.gif |