XAV-939
XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.
| Trivial name | NVP-XAV939 |
| Catalog Number | S1180 |
| Molecular Formula | C14H11F3N2OS |
| CAS# | 284028-89-3 |
| Inchi | InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20) |
| Inchi Key | KLGQSVMIPOVQAX-UHFFFAOYSA-N |
| SMILES | C1CSCC2=C1N=C(NC2=O)C3=CC=C(C=C3)C(F)(F)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/XAV-939.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s1180-xav-939-chemical-structure.png |