XAV-939
XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.
| Trivial name | NVP-XAV939 |
| Catalog Number | S1180 |
| Molecular Formula | C24H28ClN2O7PS |
| CAS# | 284028-89-3 |
| Inchi | InChI=1S/C24H25ClN2O3S.H3O4P/c1-27(17-5-6-19-9-11-21(25)12-10-19)18-20-7-3-4-8-24(20)26-31(28,29)23-15-13-22(30-2)14-16-23;1-5(2,3)4/h3-16,26H,17-18H2,1-2H3;(H3,1,2,3,4)/b6-5+; |
| Inchi Key | XRQHWVVDNMJDEQ-IPZCTEOASA-N |
| SMILES | CN(CC=CC1=CC=C(C=C1)Cl)CC2=CC=CC=C2NS(=O)(=O)C3=CC=C(C=C3)OC.OP(=O)(O)O |
| Size | 10mg |
| Supplier Page | http://www.selleckchem.com/products/XAV-939.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s1180-xav-939-chemical-structure.png |