XAV939
A Tankyrase (TNKS) inhibitor (IC50 = 110 nM for TNKS1 and 4 nM for TNKS2). Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of axin. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.
| Catalog Number | ABS-074 |
| Alternative Name(s) | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one |
| CAS# | 284028-89-3 |
| Inchi | InChI=1S/C14H11F3N2OS/c15-14(16,17)9-3-1-8(2-4-9)12-18-11-5-6-21-7-10(11)13(20)19-12/h1-4H,5-7H2,(H,18,19,20) |
| Inchi Key | KLGQSVMIPOVQAX-UHFFFAOYSA-N |
| SMILES | C1CSCC2=C1NC(=NC2=O)C3=CC=C(C=C3)C(F)(F)F |
| Size | Inquiry |
| Supplier Page | https://www.agingclocks.com/xav939-item-1538.html |