Bumetanide
Bumetanide is a loop diuretic of the sulfamyl category to treat heart failure. Bumetanide is a selective Na+-K+-Cl- cotransporter 1 (NKCC1) inhibitor, weakly inhibits NKCC2, with IC50s of 0.68 and 4.0 μM for hNKCC1A and hNKCC2A, respectively.
| Trivial name | Ro 10-6338，PF 1593 |
| Catalog Number | S1287 |
| Molecular Formula | C17H20N2O5S |
| CAS# | 28395-03-1 |
| Inchi | InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23) |
| Inchi Key | MAEIEVLCKWDQJH-UHFFFAOYSA-N |
| SMILES | CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/Bumetanide.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Bumetanide-chemical-structure-S1287.gif |