DMB
DMB (GLP-1R agonist 2, Compound 2) is an agonist of the GLP-1 receptor (GLP-1R) with a Ki of 13.25 µM. It activates GLP-1R by forming hydrogen bonds with the Tyr42, Cys71, and Ser84 residues. DMB attenuates transient focal cerebral ischemia injury and inhibits neuronal apoptosis induced by MCAO.
| Trivial name | GLP-1R agonist 2 |
| Catalog Number | E4779 |
| Molecular Formula | C19H20N4O2S2 |
| CAS# | 281209-71-0 |
| Inchi | InChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25) |
| Inchi Key | BKJIXTWSNXCKJH-UHFFFAOYSA-N |
| SMILES | CN(C(=S)C1=CC=CC=C1)NC(=O)CC(=O)NN(C)C(=S)C2=CC=CC=C2 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/dmb.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4779-DMB-chemical-structure.png |