RGT-018
RGT-018, is a potent and selective inhibitor of SOS1. It blocks the interaction of KRAS:SOS1 with an IC50 of 8 nM and inhibited KRAS signaling and the proliferation of KRAS-driven cancer cells. It may exhibit potent anticancer activity against NSCLC, colorectal cancer, and pancreatic cancer.
| Catalog Number | E4697 |
| Molecular Formula | C13H16N4O |
| CAS# | 2794934-49-7 |
| Inchi | InChI=1S/C13H16N4O/c1-13(6-3-7-15-13)12-16-9-5-2-4-8(11(14)18)10(9)17-12/h2,4-5,15H,3,6-7H2,1H3,(H2,14,18)(H,16,17)/t13-/m1/s1 |
| Inchi Key | JNAHVYVRKWKWKQ-CYBMUJFWSA-N |
| SMILES | CC1(CCCN1)C2=NC3=C(C=CC=C3N2)C(=O)N |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/rgt-018.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4697-RGT-018-chemical-structure.png |