MS41
MS41 is a highly potent and selective PROTAC degrader of eleven-nineteen leukemia (ENL) that recruits the von Hippel–Lindau (VHL) E3 ubiquitin ligase, with DC50 values of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1). It suppresses oncogenic gene expression, inhibits leukemia cell proliferation, and reduces MLL-r leukemia progression in a xenograft mouse model.
| Catalog Number | E4759 |
| Molecular Formula | C17H22N2O3 |
| CAS# | 2768610-97-3 |
| Inchi | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 |
| Inchi Key | RTKIYFITIVXBLE-QEQCGCAPSA-N |
| SMILES | CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/ms41.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4759-MS41-chemical-structure.png |