FDW028
FDW028 is a highly potent and selective inhibitor of FUT8. FDW028 demonstrates strong anti-tumor effects by promoting defucosylation and inducing lysosomal degradation of B7-H3 via the chaperone-mediated autophagy (CMA) pathway. Additionally, FDW028 suppresses the AKT/mTOR signaling pathway. FDW028 exhibits potent anti-Metastatic colorectal cancer (mCRC) activities.
| Catalog Number | E4732 |
| Molecular Formula | C13H13N3O3 |
| CAS# | 2768426-49-7 |
| Inchi | InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) |
| Inchi Key | GOTYRUGSSMKFNF-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC=C3N |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/fdw028.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4732-FDW028-chemical-structure.png |