JNJ-77242113(Icotrokinra)

Icotrokinra (JNJ-77242113, JNJ-2113, PN-235) is an orally available and selective antagonist of the IL-23 receptor. It also inhibits IL-23–induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5.6 pM and suppresses IL-23–induced IFN-γ production in NK cells with an IC50 of 18.4 pM. It also exhibits anti-inflammatory activity in a TNBS-induced colitis model in rats and holds potential for studying psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Price Not Available 5mg JNJ-77242113(Icotrokinra) Supplier Page

Trivial name	JNJ-77242113, JNJ-2113, PN-235
Catalog Number	P1252
Molecular Formula	C21H21FN2O4S
CAS#	2763602-16-8
Inchi	InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)/t15-/m1/s1
Inchi Key	LDXDSHIEDAPSSA-OAHLLOKOSA-N
SMILES	C1CC2=C(CC1NS(=O)(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4N2CCC(=O)O
Size	5mg
Supplier Page	http://www.selleckchem.com/products/jnj-77242113-icotrokinra.html
Additional Information	https://file.selleck.cn/downloads/struct/P1252-JNJ-77242113-Icotrokinra-chemical-structure.png