JNJ-77242113(Icotrokinra)

Icotrokinra (JNJ-77242113, JNJ-2113, PN-235) is an orally available and selective antagonist of the IL-23 receptor. It also inhibits IL-23–induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5.6 pM and suppresses IL-23–induced IFN-γ production in NK cells with an IC50 of 18.4 pM. It also exhibits anti-inflammatory activity in a TNBS-induced colitis model in rats and holds potential for studying psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Price Not Available 25mg JNJ-77242113(Icotrokinra) Supplier Page

Trivial name	JNJ-77242113, JNJ-2113, PN-235
Catalog Number	P1252
Molecular Formula	C12H18ClNOS
CAS#	2763602-16-8
Inchi	InChI=1S/C12H17NOS.ClH/c1-2-13-12(11-7-5-9-15-11)8-4-3-6-10(12)14;/h5,7,9,13H,2-4,6,8H2,1H3;1H
Inchi Key	ZUYKJZQOPXDNOK-UHFFFAOYSA-N
SMILES	CCNC1(CCCCC1=O)C2=CC=CS2.Cl
Size	25mg
Supplier Page	http://www.selleckchem.com/products/jnj-77242113-icotrokinra.html
Additional Information	https://file.selleck.cn/downloads/struct/P1252-JNJ-77242113-Icotrokinra-chemical-structure.png