JNJ-77242113(Icotrokinra)

Icotrokinra (JNJ-77242113, JNJ-2113, PN-235) is an orally available and selective antagonist of the IL-23 receptor. It also inhibits IL-23–induced STAT3 phosphorylation in peripheral blood mononuclear cells with an IC50 of 5.6 pM and suppresses IL-23–induced IFN-γ production in NK cells with an IC50 of 18.4 pM. It also exhibits anti-inflammatory activity in a TNBS-induced colitis model in rats and holds potential for studying psoriasis, psoriatic arthritis, and inflammatory bowel disease.

Price Not Available 100mg JNJ-77242113(Icotrokinra) Supplier Page

Trivial name	JNJ-77242113, JNJ-2113, PN-235
Catalog Number	P1252
Molecular Formula	C22H32N2O5S
CAS#	2763602-16-8
Inchi	InChI=1S/C18H22O5S.C4H10N2/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;1-2-6-4-3-5-1/h3,5,10,14-16H,2,4,6-9H2,1H3,(H,20,21,22);5-6H,1-4H2/t14-,15-,16+,18+;/m1./s1
Inchi Key	HZEQBCVBILBTEP-ZFINNJDLSA-N
Size	100mg
Supplier Page	http://www.selleckchem.com/products/jnj-77242113-icotrokinra.html
Additional Information	https://file.selleck.cn/downloads/struct/P1252-JNJ-77242113-Icotrokinra-chemical-structure.png