Claturafenib (PF-07799933)
Claturafenib (PF-07799933) is a brain-penetrant, selective, pan-mutant inhibitor of BRAF. It exhibits broad inhibition of pERK levels in HT29 cells with an IC50 value of 1.6 nM. PF-07799933 treatment displays antitumor activity against BRAFV600- and non-V600-mutant cancers preclinically and in treatment-refractory patients.
| Trivial name | Claturafenib, ARRY-440 |
| Catalog Number | E4681 |
| Molecular Formula | C24H21F3N2O4S |
| CAS# | 2754408-94-9 |
| SMILES | C1CCN(C1)S(=O)(=O)C2=CN(C(=O)C=C2)CC(=O)C3=CC=C(C=C3)C4=CC(=CC=C4)C(F)(F)F |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/pf-07799933.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4681-PF-07799933-chemical-structure.png |