Claturafenib (PF-07799933)

Claturafenib (PF-07799933) is a brain-penetrant, selective, pan-mutant inhibitor of BRAF. It exhibits broad inhibition of pERK levels in HT29 cells with an IC50 value of 1.6 nM. PF-07799933 treatment displays antitumor activity against BRAFV600- and non-V600-mutant cancers preclinically and in treatment-refractory patients.

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Trivial name	Claturafenib, ARRY-440
Catalog Number	E4681
Molecular Formula	C16H16F3NO2S
CAS#	2754408-94-9
SMILES	CC1=CC(=C(C(=C1)C)S(=O)(=O)NC2=CC=CC(=C2)C(F)(F)F)C
Size	1g
Supplier Page	http://www.selleckchem.com/products/pf-07799933.html
Additional Information	https://file.selleck.cn/downloads/struct/E4681-PF-07799933-chemical-structure.png