Gambogic Acid
Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin) activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
| Trivial name | Guttatic Acid, Guttic Acid, Beta-Guttiferrin |
| Catalog Number | S2448 |
| Molecular Formula | C21H19FN6O2 |
| CAS# | 2752-65-0 |
| Inchi | InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1 |
| Inchi Key | IIXWYSCJSQVBQM-LLVKDONJSA-N |
| SMILES | CC1C2=C(C=CC(=C2)F)C(=O)N(CC3=NN(C(=C3C4=CC(=C(N=C4)N)O1)C#N)C)C |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/gambogic-acid.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Gambogic-acid-chemical-structure-s2448.jpg |