JNJ-75276617
JNJ-75276617 (Bleximenib, Menin-MLL inhibitor 24) is an orally bioavailable, potent inhibitor of menin targeting the menin-KMT2A selective protein-protein interaction. It also acts as an inhibitor of menin-mixed-lineage leukemia 1 (menin-MLL). JNJ-75276617 displays highly potent antiproliferative activity across several acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cell lines and patient samples.
| Trivial name | Bleximenib, Menin-MLL inhibitor 24 |
| Catalog Number | E4994 |
| Molecular Formula | C26H27NO9.HCl |
| CAS# | 2654081-35-1 |
| Inchi | InChI=1S/C26H27NO9.ClH/c1-10-21(29)15(27)7-17(35-10)36-16-9-26(34,11(2)28)8-14-18(16)25(33)20-19(24(14)32)22(30)12-5-3-4-6-13(12)23(20)31;/h3-6,10,15-17,21,29,32-34H,7-9,27H2,1-2H3;1H/t10-,15-,16-,17- ,21+,26-;/m0./s1 |
| Inchi Key | JVHPTYWUBOQMBP-RVFAQHLVSA-N |
| SMILES | CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=CC=CC=C5C4=O)O)(C(=O)C)O)N)O.Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/jnj-75276617.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4994-JNJ-75276617-chemical-structure.png |