Amiloride
Amiloride (MK-870) is the first potent inhibitor of epithelial sodium channel (ENaC), inhibiting δβγ ENaC with an IC50 of 2.6 μM. It is also a typical blocker of PC2(TRPP2) channels and can be used in the research to study Autosomal dominant polycystic kidney disease (ADPKD).
| Trivial name | MK-870 |
| Catalog Number | E8150 |
| Molecular Formula | C15H24N2O |
| CAS# | 2609-46-3 |
| Inchi | InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m0/s1 |
| Inchi Key | ZSBXGIUJOOQZMP-JLNYLFASSA-N |
| SMILES | C1CC2C3CCCN4C3C(CCC4)CN2C(=O)C1 |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/amiloride.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E8150-Amiloride-chemical-structure.png |