LY3522348 | MedChemExpress (MCE)
KHK-IN-3 (Example 1) is a ketohexokinase (KHK) inhibitor. KHK-IN-3 can be used in the study of kidney disease, nonalcoholic steatohepatitis (NASH), diabetes and heart failure. KHK is a rate-limiting enzyme and fructokinase involved in fructose metabolism. KHK catalyzes the phosphorylation of fructose to fructose-1-phosphate (FIP) at the expense of ATP. The lack of feedback inhibition of fructose metabolism triggers the accumulation of downstream intermediates such as lipogenesis, gluconeogenesis, and oxidative phosphorylation[1].
Trivial name | LY3522348 |
Catalog Number | HY-149987 |
Alternative Name(s) | KHK-IN-3 |
Research Area | Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease |
CAS# | 2568608-48-8 |
Purity | 99.31% |
SMILES | C[C@@H]1N(CC1)C2=NC(C(F)(F)F)=CC(C3=CN(N=C3)CC(N4CCNCC4)=O)=N2 |
PubChem Chemical Structure ID | 155385439 |
Size | 5 mg |
Supplier Page | https://www.medchemexpress.com/khk-in-3.html |