(1S,2S)-ML-SI3 | MedChemExpress (MCE)
(1S,2S)-ML-SI3 is the trans-isomer of ML-SI3, a TRPML inhibitor. The (-)-isomer is a potent inhibitor of TRPML1 and TRPML2 (IC50=1.6 μM/2.3 μM) and a weak inhibitor of TRPML3 (IC50=12.5 μM), whereas the (+)-enantiomer is an inhibitor on TRPML1 (IC50=5.9 μM), but an activator on TRPML 2 and 3 (EC50=2.7 μM/10.8 μM)[1].
| Trivial name | (1S,2S)-ML-SI3 |
| Catalog Number | HY-134819 |
| Alternative Name(s) | (+)-trans-ML-SI3 |
| Research Area | Cancer |
| CAS# | 2563870-87-9 |
| Purity | 99.82% |
| SMILES | COC1=CC=CC=C1N2CCN([C@H]3CCCC[C@@H]3NS(C4=CC=CC=C4)(=O)=O)CC2 |
| PubChem Chemical Structure ID | 94784693 |
| Size | 100 mg |
| Supplier Page | https://www.medchemexpress.com/1s-2s-ml-si3.html |