Doxorubicin (DOX) HCl

Doxorubicin (DOX) HCl is an antibiotic agent that inhibits human DNA topoisomerase I and topoisomerase II with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK. Doxorubicin is used in the concomitant treatment of HIV-infected patients but is found to be at high risk of HBV reactivation.This product may precipitate when dissolved in PBS solution. It is recommended to prepare the stock solution in pure water and dilute with either pure water or saline to obtain the working solution.

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Trivial name	Adriamycin, NSC 123127, Hydroxydaunorubicin HCl
Catalog Number	S1208
Molecular Formula	C27H29NO11.HCl
CAS#	25316-40-9
Inchi	InChI=1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3; 1H/t10-,13-,15-,17-,22+,27-;/m0./s1
Inchi Key	MWWSFMDVAYGXBV-RUELKSSGSA-N
SMILES	CC1C(C(CC(O1)OC2CC(CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O.Cl
Size	100mg
Supplier Page	http://www.selleckchem.com/products/Adriamycin.html
Additional Information	https://file.selleck.cn/downloads/struct/Adriamycin-Doxorubicin-chemical-structure-S1208.gif