Laduviglusib (CHIR-99021)

Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.

Price Not Available 5mg Laduviglusib (CHIR-99021) Supplier Page

Trivial name	CT99021
Catalog Number	S1263
Molecular Formula	C25H28ClN3O4
CAS#	252917-06-9
Inchi	InChI=1S/C25H27N3O4.ClH/c1-4-25(31)19-11-21-22-17(12-28(21)23(29)18(19)13-32-24(25)30)15(9-10-26-14(2)3)16-7-5-6-8-20(16)27-22;/h5-8,11,14,26,31H,4,9-10,12-13H2,1-3H3;1H/t25-;/m0./s1
Inchi Key	SJKBXKKZBKCHET-UQIIZPHYSA-N
SMILES	CCC1(C2=C(COC1=O)C(=O)N3CC4=C(C5=CC=CC=C5N=C4C3=C2)CCNC(C)C)O.Cl
Size	5mg
Supplier Page	http://www.selleckchem.com/products/CHIR-99021.html
Additional Information	https://file.selleck.cn/downloads/struct/CHIR99021-chemical-structure-s1263.gif