Laduviglusib (CHIR-99021) HCl

Laduviglusib (CHIR-99021; CT99021) HCl is hydrochloride of CHIR-99021, which is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; CHIR-99021 shows greater than 500-fold selectivity for GSK-3 versus its closest homologs Cdc2 and ERK2. CHIR-99021 is a potent pharmacological activators of the Wnt/beta-catenin signaling pathway. CHIR-99021 significantly rescues light-induced autophagy and augments GR, RORα and autophagy-related proteins.

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Trivial name	CT99021 HCl
Catalog Number	S2924
Molecular Formula	C22H18Cl2N8.HCl
CAS#	1797989-42-4
Inchi	InChI=1S/C22H18Cl2N8.ClH/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19;/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32);1H
Inchi Key	SCQDMKUZHIGAIB-UHFFFAOYSA-N
SMILES	CC1=CN=C(N1)C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)Cl)NCCNC4=NC=C(C=C4)C#N.Cl
Size	5mg
Supplier Page	http://www.selleckchem.com/products/chir-99021-ct99021-hcl.html
Additional Information	https://file.selleck.cn/downloads/struct/CHIR-99021-CT99021-hcl-chemical-structure-s2924.gif