Orantinib (SU6668)

Orantinib (TSU-68, SU6668) has greatest potency against PDGFR autophosphorylation with Ki of 8 nM in a cell-free assay, but also strongly inhibits Flk-1 and FGFR1 trans-phosphorylation, little activity against IGF-1R, Met, Src, Lck, Zap70, Abl and CDK2; does not inhibit EGFR. Phase 3.

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Trivial name	TSU-68
Catalog Number	S1470
Molecular Formula	C18H18N2O3
CAS#	252916-29-3
Inchi	InChI=1S/C18H18N2O3/c1-10-12(7-8-17(21)22)11(2)19-16(10)9-14-13-5-3-4-6-15(13)20-18(14)23/h3-6,9,19H,7-8H2,1-2H3,(H,20,23)(H,21,22)/b14-9-
Inchi Key	NHFDRBXTEDBWCZ-ZROIWOOFSA-N
SMILES	CC1=C(NC(=C1CCC(=O)O)C)C=C2C3=CC=CC=C3NC2=O
Size	5mg
Supplier Page	http://www.selleckchem.com/products/TSU-68(SU6668).html
Additional Information	https://file.selleck.cn/downloads/struct/TSU-68-SU6668-chemical-structure-S1470.gif