AZD7545
AZD7545 is a potent PDHK inhibitor with IC50 of 36.8 nM and 6.4 nM for PDHK1 and PDHK2, respectively. It failed to inhibit PDHK4 at higher concentrations(>10 nM), AZD7545 stimulates PDHK4 activity.
| Trivial name | N/A |
| Catalog Number | S7517 |
| Molecular Formula | C19H18ClF3N2O5S |
| CAS# | 252017-04-2 |
| Inchi | InChI=1S/C19H18ClF3N2O5S/c1-18(28,19(21,22)23)17(27)24-15-9-8-13(10-14(15)20)31(29,30)12-6-4-11(5-7-12)16(26)25(2)3/h4-10,28H,1-3H3,(H,24,27)/t18-/m1/s1 |
| Inchi Key | DTDZLJHKVNTQGZ-GOSISDBHSA-N |
| SMILES | CC(C(=O)NC1=C(C=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)N(C)C)Cl)(C(F)(F)F)O |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/azd7545.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AZD7545-chemical-structure-s7517.gif |