DMT-2′-O-MOE-A(Bz)-CE Phosphoramidite

N6-Benzoyl-5′-O-DMT-2′-O-(2-methoxyethyl)adenosine 3′-CE phosphoramidite is used to incorporate 2′-O-methoxyethyl-modified A into oligonucleotide phosphoramidites, which is useful for antisense RNA. The 2′-MOE backbone provides stronger duplex stability, significant nuclease resistance and relatively low toxicity.

Catalog Number PIPB-0316
Alternative Name(s) 2'-O-MOE-A(Bz)-3'-phosphoramidite N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-3-(2-methoxyethoxy)oxolan-2-yl]purin-6-yl]benzamide (2R,3R,4R,5R)-5-(6-Benzamido-9H-purin-9-yl)-2-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-(2-methoxyethoxy)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite
Research Area Phosphoramidites Series
Molecular Formula C50H58N7O9P
CAS# 251647-53-7
SMILES CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1OCCOC)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
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