Thyroid hormone receptor antagonist (1-850) | MedChemExpress (MCE)
Thyroid hormone receptor antagonist (1-850) is a competitive, selective and high-affinity thyroid hormone receptor (TR) antagonist with an IC50 of 1.5 μM for antagonizing the effect of T3 on TR. Thyroid hormone receptor antagonist (1-850) blocks T3-mediated interaction of TRα and TRβ with nuclear receptor coactivator. Thyroid hormone receptor antagonist (1-850) has no effect on the activity of RARα[1][2][3].
| Trivial name | Thyroid hormone receptor antagonist (1-850) |
| Catalog Number | HY-127024 |
| Research Area | Metabolic Disease |
| CAS# | 251310-57-3 |
| Purity | ≥98.0% |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1)NNC(/C=C2CCN(CC\2)C3=CC=C(C=C3)[N+]([O-])=O)=O |
| Size | 1 mg |
| Supplier Page | https://www.medchemexpress.com/thyroid-hormone-receptor-antagonist-1-850.html |