LC-2
LC-2 is a first PROTAC capable of degrading endogenous KRASG12C with DC50s between 0.25 μM and 0.76 μM. LC-2 covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling.
| Trivial name | PROTAC KRASG12C Degrader-LC-2 |
| Catalog Number | S6996 |
| Molecular Formula | C59H71ClFN11O7S |
| CAS# | 2502156-03-6 |
| Inchi | #N/A |
| Inchi Key | #N/A |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/lc-2.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s6996-protac-krasg12c-degrader-lc-2-chemical-structure.gif |