SD-436
SD-436 is a potent and selective PROTAC degrader of STAT3 with a DC50 of 0.5 μM. It induces complete and long-lasting tumor regression in leukemia and lymphoma xenograft models in mice.
| Catalog Number | E5802 |
| Molecular Formula | C28H28O3 |
| CAS# | 2497585-50-7 |
| Inchi | InChI=1S/C28H28O3/c1-31-26-7-6-23(21-2-3-22-12-24(27(29)30)5-4-20(22)11-21)13-25(26)28-14-17-8-18(15-28)10-19(9-17)16-28/h2-7,11-13,17-19H,8-10,14-16H2,1H3,(H,29,30) |
| Inchi Key | LZCDAPDGXCYOEH-UHFFFAOYSA-N |
| SMILES | COC1=C(C=C(C=C1)C2=CC3=C(C=C2)C=C(C=C3)C(=O)O)C45CC6CC(C4)CC(C6)C5 |
| Size | 100mg |
| Supplier Page | http://www.selleckchem.com/products/sd-436.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5802-SD-436-chemical-structure.png |