SB-328437
SB-328437 is a non-peptide small molecule, potent and selective antagonist of CCR3 with an IC50 of 4.5 nM. It is important for eosinophil recruitment, a process that is thought to be crucial in the pathology of several inflammatory diseases including asthma, allergic rhinitis, and eczema.
| Catalog Number | E4715 |
| Molecular Formula | C21H21FN6O |
| CAS# | 247580-43-4 |
| Inchi | InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29) |
| Inchi Key | PIQCTGMSNWUMAF-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=C(C5=C(C=CC=C5F)NC4=O)N |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/sb-328437.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4715-SB-328437-chemical-structure.png |