SB-328437
SB-328437 is a non-peptide small molecule, potent and selective antagonist of CCR3 with an IC50 of 4.5 nM. It is important for eosinophil recruitment, a process that is thought to be crucial in the pathology of several inflammatory diseases including asthma, allergic rhinitis, and eczema.
| Catalog Number | E4715 |
| Molecular Formula | C24H25ClFN5O3 |
| CAS# | 247580-43-4 |
| Inchi | InChI=1S/C24H25ClFN5O3/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16/h2,4-5,12-15H,1,3,6-11H2,(H,30,32)(H,27,28,29) |
| Inchi Key | OMZCMEYTWSXEPZ-UHFFFAOYSA-N |
| SMILES | C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/sb-328437.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E4715-SB-328437-chemical-structure.png |