Surfactin C1 is an amphiphilic biosurfactants. Surfactin C1 inhibits leukemic cell (HL-60) adhesion to human umbilical vein endothelial cells (HUVEC). Surfactin C1 inhibits adhesion melecules expression, such as ICAM-1 and VCAM-1.In Vitro:Surfactin C1 (0.3-10 μg/mL; 24 h) inhibits the adhesion of leukemic cell and monocyte cell to HUVEC, stimulated by LPS.
Surfactin C1 (3 μg/mL; 1 h) inhibits LPS-induced expression of adhesion molecules.
Surfactin C1 (3 μg/mL; 1 h) inhibits the interaction of lipid A/LBP.