RWJ52353 hydrochloride | MedChemExpress (MCE)
RWJ-52353 hydrochloride is an orally potent, highly selective α2D adrenergic receptor agonist (Ki: 1.5 nM) with potential analgesic effects. RWJ-52353 hydrochloride demonstrated analgesic activity in abdominal tests in rats and mice, and improved agitation in mice in the hot plate test and tail flick test. RWJ-52353 hydrochloride also regulates the organic cation transporter (OCT) subtype, inhibiting rOCT1 and rOCT2 with IC50s of 100 μM and 20 μM respectively; it also activates rOCT3, affecting [3H]-1- in cells. Methyl-4-phenylpyridinium ([3H]MPP) transport[1][2].
Trivial name | RWJ52353 hydrochloride |
Catalog Number | HY-103216A |
Research Area | Neurological Disease |
CAS# | 245744-13-2 |
Purity | ≥98.0% |
SMILES | C1(C2=CCCC3=C2C=CS3)=CN=CN1.Cl |
Size | 1 mg |
Supplier Page | https://www.medchemexpress.com/rwj52353-hydrochloride.html |