Zoniporide dihydrochloride
Zoniporide dihydrochloride is a potent sodium-hydrogen exchanger isoform 1 (NHE1) inhibitor with selectivity over other NHE isoforms (Ki = 14, 2200 and 220000 nM for human NHE1, human NHE2 and rat NHE3, respectively). Zoniporide inhibits NHE1-dependent 22Na+ uptake in vitro (IC50 = 14 nM) and protects against cardiac ischemia-reperfusion injury. Zoniporide also exhibits inhibitory effects on MMP2/9 in breast cancer cells.
| Catalog Number | 241799-10-0 |
| Alternative Name(s) | [1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidine dihydrochloride; CP 597396 |
| Molecular Formula | C17H16N6O.2HCl |
| CAS# | 241799-10-0 |
| Purity | ≥99% |
| Inchi | InChI=1S/C17H16N6O.2ClH/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);2*1H |
| Inchi Key | ARZNPJAGKWHEHT-UHFFFAOYSA-N |
| Size | Please inquire |
| Supplier Page | https://www.bocsci.com/zoniporide-dihydrochloride-cas-241799-10-0-item-170437.html |