SJF620 is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN.IC50 & Target: DC50: 7.9 nM (BTK)In Vitro: SJF620 is a PROTAC that retains potent degradation of BTK in cellular assays with a DC50 of 7.9 nM in Burkitt lymphoma cell line NAMALWA.In Vivo: SJF620 has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802.