ACBI1
ACBI1 is a potent and cooperative PROTAC degrader of SMARCA2, SMARCA4 and PBRM1 with DC50 of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 induces anti-proliferative effects and apoptosis.
| Trivial name | N/A |
| Catalog Number | S9612 |
| Molecular Formula | C49H58FN9O7S |
| CAS# | 2375564-55-7 |
| SMILES | CC1=C(SC=N1)C2=CC(=C(CNC(=O)C3CC(O)CN3C(=O)C(NC(=O)C4(F)CC4)C(C)(C)C)C=C2)OCCOC5=CC=C(CN6CCN(CC6)C7=C(N)N=NC(=C7)C8=C(O)C=CC=C8)C=C5 |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/acbi1.html |
| Additional Information | https://file.selleck.cn/downloads/struct/s9612-acbi1-chemical-structure.gif |