SR-717 lithium
SR-717 lithium is a non-nucleotide STING agonist that demonstrates broad interspecies and interallelic specificity with EC50 of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 (cGAS KO) cell lines, respectively. SR-717 lithium also induces the expression of clinically relevant targets, including programmed cell death 1 ligand 1 (PD-L1), in a STING-dependent manner. SR-717 lithium exhibits antitumor activity.
Trivial name | N/A |
Catalog Number | S0853 |
Molecular Formula | C15H8F2LiN5O3 |
CAS# | 2375421-09-1 |
SMILES | [Li]OC(=O)C1=C(NC(=O)C2=NN=C(C=C2)[N]3C=CN=C3)C=C(F)C(=C1)F |
Size | 25mg |
Supplier Page | http://www.selleckchem.com/products/sr-717.html |
Additional Information | https://file.selleck.cn/downloads/struct/s0853-sr-717-lithium-chemical-structure.gif |