Decitabine
Decitabine is a DNA methyltransferase inhibitor, incorporating into DNA and resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. It is used to treat myelodysplastic syndrome (MDS). Decitabine induces cell cycle arrest and apoptosis in various cancer cell lines.
| Trivial name | Deoxycytidine, 5-aza-2'-deoxycytidine, 5-AZA-dC, 5-aza-CdR,NSC 127716 |
| Catalog Number | S1200 |
| Molecular Formula | C23H19F3N8O |
| CAS# | 2353-33-5 |
| Inchi | InChI=1S/C23H19F3N8O/c24-13-2-1-3-14(10-13)34-12-28-20-21(31-23(32-22(20)34)33-6-8-35-9-7-33)27-11-17-29-16-5-4-15(25)18(26)19(16)30-17/h1-5,10,12H,6-9,11H2,(H,29,30)(H,27,31,32) |
| Inchi Key | CEBMEQPREMCWOL-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=NC(=C3C(=N2)N(C=N3)C4=CC(=CC=C4)F)NCC5=NC6=C(N5)C=CC(=C6F)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/Decitabine.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Decitabine-chemical-structure-S1200.gif |