GLPG3312
GLPG3312 is a potent and selective inhibitor of pan-SIK, with an IC50 of 2.0 nM for SIK1, 0.7 nM for SIK2, and 0.6 nM for SIK3. It demonstrates anti-inflammatory and immunoregulatory activities in vitro in human primary myeloid cells and in vivo in mouse models.
| Catalog Number | E5798 |
| Molecular Formula | C25H43NO18 |
| CAS# | 2340388-72-7 |
| Inchi | InChI=1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1 |
| Inchi Key | XUFXOAAUWZOOIT-SXARVLRPSA-N |
| SMILES | CC1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)NC4C=C(C(C(C4O)O)O)CO |
| Size | 1mg |
| Supplier Page | http://www.selleckchem.com/products/glpg3312.html |
| Additional Information | https://file.selleck.cn/downloads/struct/E5798-GLPG3312-chemical-structure.png |