LDHA-IN-3
LDHA-IN-3, a selenobenzene derivative, is a potent noncompetitive inhibitor of Lactate Dehydrogenase A (LDHA), with an IC50 of 145.2 nM. It exhibits significant anti-tumor activity, effectively reducing LDHA activity and lactate production under both normoxic and hypoxic conditions. It also induces mitochondria-mediated apoptosis through the generation of reactive oxygen species.
Catalog Number | E4772 |
Molecular Formula | C23H28N8OS |
CAS# | 227010-33-5 |
Inchi | InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) |
Inchi Key | GCIKSSRWRFVXBI-UHFFFAOYSA-N |
SMILES | CC1=CC(=NN1)NC2=CC(=NC(=N2)SC3=CC=C(C=C3)NC(=O)C4CC4)N5CCN(CC5)C |
Size | 1g |
Supplier Page | http://www.selleckchem.com/products/ldha-in-3.html |
Additional Information | https://file.selleck.cn/downloads/struct/E4772-LDHA-IN-3-chemical-structure.png |