TQB3804
TQB3804 is a selective and potent EGFR kinase inhibitor with IC50 of 0.46 nM, 0.13 nM, 0.26 nM, 0.19 nM and 1.07 nM for for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, EGFRL858R/T790M and EGFRWT, respectively. TQB3804 (EGFR-IN-7) shows anti-tumor activity.
| Trivial name | EGFR-IN-7 |
| Catalog Number | S6698 |
| Molecular Formula | C32H41BrN9O2P |
| CAS# | 2267329-76-8 |
| Inchi | InChI=1S/C32H41BrN9O2P/c1-21-18-26(28(44-3)19-27(21)42-12-8-22(9-13-42)41-16-14-40(2)15-17-41)38-32-36-20-23(33)31(39-32)37-25-7-6-24-29(35-11-10-34-24)30(25)45(4,5)43/h6-7,10-11,18-20,22H,8-9,12-17H2 ,1-5H3,(H2,36,37,38,39) |
| Inchi Key | ZYSKXRAGBGLELB-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C=C1N2CCC(CC2)N3CCN(CC3)C)OC)NC4=NC=C(C(=N4)NC5=C(C6=NC=CN=C6C=C5)P(=O)(C)C)Br |
| Size | 25mg |
| Supplier Page | http://www.selleckchem.com/products/tqb-3804-egrf-in-7.html |
| Additional Information | https://file.selleck.cn/downloads/struct/tqb3804-egfr-in-7-chemical-structure-s6698.gif |