RU.521

RU.521 (RU320521) is an active, potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS) that inhibits the cGAS-mediated signaling with IC50 of 700 nM. RU.521 binds to the cGAS/dsDNA complex with Kd of 36.2 nM.

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Trivial name	RU320521
Catalog Number	S6841
Molecular Formula	C19H12Cl2N4O3
CAS#	2262452-06-0
SMILES	CC1=C(C(=O)N(N1)C2=NC3=C(N2)C=CC(=C3Cl)Cl)C4C5=CC=CC=C5C(=O)O4
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/ru-521.html
Additional Information	https://file.selleck.cn/downloads/struct/s6841-ru521-ru320521-chemical-structure.gif